期刊
NATURE METHODS
卷 10, 期 12, 页码 1196-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2693
关键词
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资金
- European Molecular Biology Laboratory
- European Community [HEALTH-F4-2007-201052, HEALTH-F4-2010-261376]
- Novo Nordisk Foundation
- Lundbeck Foundation
- Heidelberg Institute for Theoretical Studies
- Deutsche Forschungsgemeinschaft [STA 860/2, STA 860/3]
- Metagenopolis [ANR-11-DPBS-0001]
- European Research Council [250172, 268985]
- European Research Council (ERC) [268985] Funding Source: European Research Council (ERC)
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
To quantify known and unknown microorganisms at species-level resolution using shotgun sequencing data, we developed a method that establishes metagenomic operational taxonomic units (mOTUs) based on single-copy phylogenetic marker genes. Applied to 252 human fecal samples, the method revealed that on average 43% of the species abundance and 58% of the richness cannot be captured by current reference genome-based methods. An implementation of the method is available at http://www.bork.embl.de/software/mOTU/.
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