期刊
NATURE METHODS
卷 10, 期 3, 页码 265-269出版社
NATURE PORTFOLIO
DOI: 10.1038/NMETH.2367
关键词
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资金
- European Research Council
- Knut and Alice Wallenberg Foundation
- Vetenskapsradet
- Goran Gustafsson Foundation
- Wenner-Gren Foundations
- Center for Biomembrane Research
We provide an analytical tool based on a variational Bayesian treatment of hidden Markov models to combine the information from thousands of short single-molecule trajectories of intracellularly diffusing proteins. The method identifies the number of diffusive states and the state transition rates. Using this method we have created an objective interaction map for Hfq, a protein that mediates interactions between small regulatory RNAs and their mRNA targets.
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