期刊
NATURE METHODS
卷 10, 期 10, 页码 992-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.2605
关键词
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资金
- US National Institutes of Health [R21 DA025725, RC1 DA028779, GM085394, U01 HG004264, U01 ES017154]
- University of Chicago Comprehensive Cancer Center
Variability in the quality of antibodies to histone post-translational modifications (PTMs) is a widely recognized hindrance in epigenetics research. Here, we produced recombinant antibodies to the trimethylated lysine residues of histone H3 with high specificity and affinity and no lot-to-lot variation. These recombinant antibodies performed well in common epigenetics applications, and enabled us to identify positive and negative correlations among histone PTMs.
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