期刊
NATURE METHODS
卷 10, 期 8, 页码 747-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.2522
关键词
-
资金
- US National Institutes of Health [GM085530, HG002096-11]
We report an in vitro selection strategy to identify RNA sequences that mediate cap-independent initiation of translation. This method entails mRNA display of trillions of genomic fragments, selection for initiation of translation and high-throughput deep sequencing. We identified >12,000 translation-enhancing elements (TEEs) in the human genome, generated a high-resolution map of human TEE-bearing regions (TBRs), and validated the function of a subset of sequences in vitro and in cultured cells.
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