相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing
Thomas A. Hopf et al.
CELL (2012)
ZINC: A Free Tool to Discover Chemistry for Biology
John J. Irwin et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Structure-Functional Selectivity Relationship Studies of β-Arrestin-Biased Dopamine D2 Receptor Agonists
Xin Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
ChEMBL: a large-scale bioactivity database for drug discovery
Anna Gaulton et al.
NUCLEIC ACIDS RESEARCH (2012)
Identifying mechanism-of-action targets for drugs and probes
Elisabet Gregori-Puigjane et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization
Eelke van der Horst et al.
BMC BIOINFORMATICS (2010)
Extended-Connectivity Fingerprints
David Rogers et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2010)
Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications
Natasha T. Snider et al.
PHARMACOLOGICAL REVIEWS (2010)
N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: Selective and Nonbasic κ-Opioid Receptor Ligands
Kevin J. Frankowski et al.
ACS MEDICINAL CHEMISTRY LETTERS (2010)
Definition of the G Protein-Coupled Receptor Transmembrane Bundle Binding Pocket and Calculation of Receptor Similarities for Drug Design
David E. Gloriam et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Predicting new molecular targets for known drugs
Michael J. Keiser et al.
NATURE (2009)
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness
Sarah A. Scott et al.
NATURE CHEMICAL BIOLOGY (2009)
Quantifying the relationships among drug classes
Jerome Hert et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)
Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists
Yuan Cheng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
N-Desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity
Niels H. Jensen et al.
NEUROPSYCHOPHARMACOLOGY (2008)
From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling
Wolfgang Guba et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Design and synthesis of novel hydantoin-containing melanin-concentrating hormone receptor antagonists
Fabrice Balavoine et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure
Andreas Bender et al.
CHEMMEDCHEM (2007)
Relating protein pharmacology by ligand chemistry
Michael J. Keiser et al.
NATURE BIOTECHNOLOGY (2007)
Global mapping of pharmacological space
Gaia V. Paolini et al.
NATURE BIOTECHNOLOGY (2006)
Can we rationally design promiscuous drugs?
AL Hopkins et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2006)
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
M Watanabe et al.
NATURE (2006)
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
CM Revankar et al.
SCIENCE (2005)
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
BL Roth et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
From magic bullets to designed multiple ligands
R Morphy et al.
DRUG DISCOVERY TODAY (2004)
Novel technologies for virtual screening
T Lengauer et al.
DRUG DISCOVERY TODAY (2004)
The Pfam protein families database
A Bateman et al.
NUCLEIC ACIDS RESEARCH (2004)
MEGA3: Integrated software for molecular evolutionary genetics analysis and sequence alignment
S Kumar et al.
BRIEFINGS IN BIOINFORMATICS (2004)
The G-protein-coupled receptors in the human genome form five main families.: Phylogenetic analysis, paralogon groups, and fingerprints
R Fredriksson et al.
MOLECULAR PHARMACOLOGY (2003)
An efficient algorithm for large-scale detection of protein families
AJ Enright et al.
NUCLEIC ACIDS RESEARCH (2002)