期刊
NATURE METHODS
卷 9, 期 3, 页码 266-U64出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1892
关键词
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资金
- National Natural Science Foundation of China [31170815, 31071260, 90713026]
- 863 Program [2006AA02Z160]
- Fok Ying Tung Education Foundation [111022]
- Shanghai Institutions of Higher Learning
- Dawn Program of Shanghai Education Commission [11SG31]
- Ministry of Education of China [20100074110010]
- Fundamental Research Funds for the Central Universities
- 111 Project [B07023]
We developed a light-switchable transgene system based on a synthetic, genetically encoded light-switchable transactivator. The transactivator binds promoters upon blue-light exposure and rapidly initiates transcription of target transgenes in mammalian cells and in mice. This transgene system provides a robust and convenient way to spatiotemporally control gene expression and can be used to manipulate many biological processes in living systems with minimal perturbation.
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