期刊
NATURE METHODS
卷 9, 期 6, 页码 588-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1994
关键词
-
资金
- US National Institutes of Health [R01GM068110, R24GM078369, R01HL093766, R01HG00249]
The widespread use of zinc-finger nucleases (ZFNs) for genome engineering is hampered by the fact that only a subset of sequences can be efficiently recognized using published finger archives. We describe a set of validated two-finger modules that complement existing finger archives and expand the range of ZFN-accessible sequences threefold. Using this archive, we introduced lesions at 9 of 11 target sites in the zebrafish genome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据