期刊
NATURE METHODS
卷 9, 期 5, 页码 477-U92出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1945
关键词
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资金
- US National Institutes of Health [5R01HD055380, RC1GM090825, T32 GM007491]
Modification patterns of heparan sulfate coordinate protein function in metazoans, yet in vivo imaging of such non-genetically encoded structures has been impossible. Here we report a transgenic method in Caenorhabditis elegans that allows direct live imaging of specific heparan sulfate modification patterns. This experimental approach reveals a dynamic and cell-specific heparan sulfate landscape and could in principle be adapted to visualize and analyze any extracellular molecule in vivo.
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