期刊
NATURE METHODS
卷 8, 期 11, 页码 919-931出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1735
关键词
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资金
- US National Institutes of Health [R01 AI066975, R01 GM089846]
- US National Science Foundation [MCB 0644278]
Many recently discovered noncoding RNAs do not fold into a single native conformation but sample many different conformations along their free-energy landscape to carry out their biological function. Here we review solution-state NMR techniques that measure the structural, kinetic and thermodynamic characteristics of RNA motions spanning picosecond to second timescales at atomic resolution, allowing unprecedented insights into the RNA dynamic structure landscape. From these studies a basic description of the RNA dynamic structure landscape is emerging, bringing new insights into how RNA structures change to carry out their function as well as applications in RNA-targeted drug discovery and RNA bioengineering.
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