期刊
NATURE METHODS
卷 7, 期 5, 页码 395-U81出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1448
关键词
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资金
- Knut and Alice Wallenberg Foundation
- Swedish Cancer Foundation
- Goran Gustafsson Foundation
- Erik K. Fernstrom Foundation
- Swedish Research Council
- European Union [FP7/2007-2013, HEALTH-F4-2008-201418]
Increasing knowledge about the heterogeneity of mRNA expression within cell populations highlights the need to study transcripts at the level of single cells. We present a method for detection and genotyping of individual transcripts based on padlock probes and in situ target-primed rolling-circle amplification. We detect a somatic point mutation, differentiate between members of a gene family and perform multiplex detection of transcripts in human and mouse cells and tissue.
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