期刊
NATURE METHODS
卷 7, 期 12, 页码 973-U48出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1524
关键词
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资金
- US National Institutes of Health [R01 NS039402, R01 MH064748, R01 DK81584]
- Howard Hughes Medical Institute
Dimerizers allowing inducible control of protein-protein interactions are powerful tools for manipulating biological processes. Here we describe genetically encoded light-inducible protein-interaction modules based on Arabidopsis thaliana cryptochrome 2 and CIB1 that require no exogenous ligands and dimerize on blue-light exposure with subsecond time resolution and subcellular spatial resolution. We demonstrate the utility of this system by inducing protein translocation, transcription and Cre recombinase-mediated DNA recombination using light.
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