期刊
NATURE METHODS
卷 7, 期 11, 页码 897-U45出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1512
关键词
-
资金
- Medical Faculty, University Bonn
- Deutsche Forschungsgemeinschaft [FL 276/3-3]
- European Community Network of Excellence [LSHB-CT-2005-512146]
Electrical stimulation is the standard technique for exploring electrical behavior of heart muscle, but this approach has considerable technical limitations. Here we report expression of the light-activated cation channel channelrhodopsin-2 for light-induced stimulation of heart muscle in vitro and in mice. This method enabled precise localized stimulation and constant prolonged depolarization of cardiomyocytes and cardiac tissue resulting in alterations of pacemaking, Ca(2+) homeostasis, electrical coupling and arrhythmogenic spontaneous extrabeats.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据