期刊
NATURE METHODS
卷 7, 期 4, 页码 287-289出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1439
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资金
- US National Institutes of Health (NIH) [U19 AI057229]
- Brennan family
- National Science Foundation [DMS-9971405, N01-HV-28183, AI077821, R21 AI075256, DMS-0505676]
- NIH [2R01 CA 72028-07]
- DIVISION OF HEART AND VASCULAR DISEASES [N01HV028183] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R01CA072028] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL028183] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI077821, U19AI090019, U19AI057229, R21AI075256] Funding Source: NIH RePORTER
We describe cell type-specific significance analysis of microarrays (csSAM) for analyzing differential gene expression for each cell type in a biological sample from microarray data and relative cell-type frequencies. first, we validated csSAM with predesigned mixtures and then applied it to whole-blood gene expression datasets from stable post-transplant kidney transplant recipients and those experiencing acute transplant rejection, which revealed hundreds of differentially expressed genes that were otherwise undetectable.
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