期刊
NATURE METHODS
卷 7, 期 9, 页码 729-U88出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1488
关键词
-
资金
- Grants-in-Aid for Scientific Research [21687007] Funding Source: KAKEN
We report ultrasensitive Ca2+ indicators, yellow cameleon-Nano (YC-Nano), developed by engineering the Ca2+-sensing domain of a genetically encoded Ca2+ indicator, YC2.60 or YC3.60. Their high Ca2+ affinities (K-d = 15-140 nM) and large signal change (1,450%) enabled detection of subtle Ca2+ transients associated with intercellular signaling dynamics and neuronal activity, even in 100,000-cell networks. These indicators will be useful for studying information processing in living multicellular networks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据