期刊
NATURE METHODS
卷 7, 期 2, 页码 126-U58出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1412
关键词
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资金
- University of Washington Royalties Research Fund
- US National Institutes of Health [R01-MH079292, R21-DA024140, R01-DA014486]
- [F32-DA024540]
- [T32-AA007455]
- [T32-GM007270]
- [T32-DA007278]
Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice.
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