期刊
NATURE METHODS
卷 6, 期 9, 页码 651-U39出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1365
关键词
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资金
- European Structural Genomics
- Spanish Ministry of Science and Innovation [BIO2006-06653]
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft [DFG-IRTG1422]
- Max Planck Society
- Consejo Superior de Investigaciones Cientificas [I3PMas_08_00057]
- ICREA Funding Source: Custom
Ab initio macromolecular phasing has been so far limited to small proteins diffracting at atomic resolution (beyond 1.2 angstrom) unless heavy atoms are present. We describe a general ab initio phasing method for 2 angstrom data, based on combination of localizing model fragments such as small alpha-helices with Phaser and density modification with SHELXE. We implemented this approach in the program Arcimboldo to solve a 222-amino-acid structure at 1.95 angstrom.
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