期刊
NATURE METHODS
卷 7, 期 1, 页码 53-U10出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1409
关键词
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资金
- Schering Foundation
- US National Institutes of Health Director's Innovator Award
- Harvard Stem Cell Institute
- Massachusetts General Hospital
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD003266] Funding Source: NIH RePORTER
The derivation of induced pluripotent stem cells (iPSCs) usually involves the viral introduction of reprogramming factors into somatic cells. Here we used gene targeting to generate a mouse strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the induction of pluripotency in various somatic cell types. As these 'reprogrammable mice' can be easily bred, they are a useful tool to study the mechanisms underlying cellular reprogramming.
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