期刊
NATURE METHODS
卷 6, 期 7, 页码 497-U38出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1344
关键词
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资金
- National Institutes of Health [U19AI057229]
- Melinda Gates Foundation
- Challenges Explorations
- The Howard Hughes Medical Institute
- American Cancer Society, California Division, Steven Stanley
- Edward Albert Bielfelt postdoctoral fellowship
- National Science Foundation
- Damon Runyon
The direct detection of antigen-specific T cells using tetramers of soluble peptide-major histocompatibilty complex (pMHC) molecules is widely used in both basic and clinical immunology. However, the number of specificities that can be assessed simultaneously has been a major limitation. Here we describe and validate a method using combinations of fluorescent pMHC tetramers to simultaneously detect and enrich for many (>= 15) T-cell specificities in a single human blood sample.
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