期刊
NATURE METHODS
卷 5, 期 12, 页码 1023-1025出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1267
关键词
-
资金
- Wellcome Trust
Sylamer is a method for detecting microRNA target and small interfering RNA off-target signals in 3 ' untranslated regions from a ranked gene list, sorted from upregulated to downregulated, after a microRNA perturbation or RNA interference experiment. The output is a landscape plot that tracks occurrence biases using hypergeometric P-values for all words across the gene ranking. We demonstrated the utility, speed and accuracy of this approach on several datasets.
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