期刊
NATURE METHODS
卷 5, 期 4, 页码 315-318出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1192
关键词
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资金
- NHLBI NIH HHS [N01 HV028179, N01HV28179, N01-HV-28179] Funding Source: Medline
We describe a method to identify cross-linked peptides from complex samples and large protein sequence databases by combining isotopically tagged cross-linkers, chromatographic enrichment, targeted proteomics and a new search engine called xQuest. This software reduces the search space by an upstream candidate-peptide search before the recombination step. We showed that xQuest can identify cross-linked peptides from a total Escherichia coli lysate with an unrestricted database search.
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