期刊
NATURE METHODS
卷 5, 期 6, 页码 475-489出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1215
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资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM037006, R01GM081025, R01GM062357] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM037006-19, R01 GM081025-02, GM081025, GM037006, R01 GM037006, GM062357, R01 GM062357-07, R01 GM081025, R01 GM062357] Funding Source: Medline
Single-molecule microscopy has evolved into the ultimate-sensitivity toolkit to study systems from small molecules to living cells, with the prospect of revolutionizing the modern biosciences. Here we survey the current state of the art in single-molecule tools including fluorescence spectroscopy, tethered particle microscopy, optical and magnetic tweezers, and atomic force microscopy. We also provide guidelines for choosing the right approach from the available single-molecule toolkit for applications as diverse as structural biology, enzymology, nanotechnology and systems biology.
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