期刊
NATURE METHODS
卷 5, 期 3, 页码 227-229出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.1183
关键词
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资金
- NCI NIH HHS [R01 CA080077, 2 RO1 CA 80077] Funding Source: Medline
- NIGMS NIH HHS [R37 GM32741, R37 GM032741-24, R37 GM032741] Funding Source: Medline
We developed a cell division-activated Cre-lox system for stochastic recombination of loxP-flanked loci in mice. Cre activation by frameshift reversion is modulated by DNA mismatch-repair status and occurs in individual cells surrounded by normal tissue, mimicking spontaneous cancer-causing mutations. This system should be particularly useful for delineating pathways of neoplasia, and determining the developmental and aging consequences of specific gene alterations.
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