期刊
NATURE MEDICINE
卷 20, 期 2, 页码 139-142出版社
NATURE PORTFOLIO
DOI: 10.1038/nm.3445
关键词
-
资金
- American Foundation for AIDS Research [108302-51-RGRL]
- US National Institutes of Health [AI098487, AI106468, AI089339, AI098480, AI100699, AI074415]
- Clinical Scientist Development Award from the Doris Duke Charitable Foundation [2009034]
- European Molecular Biology Laboratory
- Tosteson postdoctoral fellowship award from Massachusetts General Hospital
- Mark and Lisa Schwartz Foundation
- Bill & Melinda Gates Foundation
Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4(+) T memory stem cells (T-SCM cells) harbor high per-cell levels of HIV-1 DNA and make increasing contributions to the total viral CD4(+) T cell reservoir over time. Moreover, we conducted phylogenetic studies that suggested long-term persistence of viral quasispecies in CD4(+) T-SCM cells. Thus, HIV-1 may exploit the stem cell characteristics of cellular immune memory to promote long-term viral persistence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据