期刊
NATURE MEDICINE
卷 19, 期 1, 页码 35-42出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3028
关键词
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资金
- Telethon [GGP09227]
- Fondazione Roma
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR)
- Ministero della Salute
- EU (Angioscaff)
- Fondazione Institut Pasteur-Cenci Bolognetti
- US National Institutes of Health (NIH) [R01 DK056638, HL69438, HL097819, HL097700, HL116340]
- NIH [DK57501, R01 DE018248, R01 EB009663]
- National Institute of Dental and Craniofacial Research (NIDCR), NIH [DE019412, DE016513]
- Division of Intramural Research, NIDCR of the Intramural Research Program, NIH, Department of Health and Human Services
Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only at elucidating their nature and unique properties but also developing cell-based therapies for a diverse range of diseases. More than three decades have passed since the original formulation of the concept, revolutionary at the time, that multiple connective tissues could emanate from a common progenitor or stem cell retained in the postnatal bone marrow. Despite the many important advances made since that time, substantial ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs. These uncertainties have a major impact on their envisioned therapeutic use.
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