期刊
NATURE MEDICINE
卷 20, 期 1, 页码 93-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3416
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资金
- Cancer Research UK Programme [C197/A3514]
- Leukemia & Lymphoma Society
- European Union Seventh Framework Programme under the Marie Curie Initial Training Network METAFLUX [264780]
- Intra-European Marie Curie (FP7-PEOPLE-2009-IEF, Imaging Lymphoma) fellowship
- Long-term European Molecular Biology Organization fellowship [EMBO-ALT-1145-2009]
- Cancer Research UK [16465, 17242] Funding Source: researchfish
In this study, we monitored glycolysis in mouse lymphoma and lung tumors by measuring the conversion of hyperpolarized [U-H-2, U-C-13]glucose to lactate using C-13 magnetic resonance spectroscopy and spectroscopic imaging. We observed labeled lactate only in tumors and not in surrounding normal tissue or other tissues in the body and found that it was markedly decreased at 24 h after treatment with a chemotherapeutic drug. We also detected an increase in a resonance assigned to 6-phosphogluconate in the pentose phosphate pathway. This technique could provide a new way of detecting early evidence of tumor treatment response in the clinic and of monitoring tumor pentose phosphate pathway activity.
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