期刊
NATURE MEDICINE
卷 19, 期 5, 页码 631-634出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3017
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资金
- S.E. from the Swedish Research Council [2009-2590, 2010-3281]
- Knut and Alice Wallenberg Foundation
- Sahlgrenska's University Hospital (LUA-ALF)
- EU [HEALTH-F2-2011-278373]
- IngaBritt and Arne Lundgren Foundation
- Soderberg Foundation
- King Gustaf V and Queen Victoria Freemason Foundation
- Swedish Foundation for Strategic Research through the Center for Cardiovascular and Metabolic Research
- Fritz Thyssen Stiftung
The previously observed supraclavicular depot of brown adipose tissue (BAT) in adult humans was commonly believed to be the equivalent of the interscapular thermogenic organ of small mammals. This view was recently disputed(1) on the basis of the demonstration that this depot consists of beige (also called brite) brown adipocytes, a newly identified type of brown adipocyte that is distinct from the classical brown adipocytes that make up the interscapular thermogenic organs of other mammals. A combination of high-resolution imaging techniques and histological and biochemical analyses showed evidence for an anatomically distinguishable interscapular BAT (iBAT) depot in human infants that consists of classical brown adipocytes, a cell type that has so far not been shown to exist in humans. On the basis of these findings, we conclude that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.
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