期刊
NATURE MEDICINE
卷 19, 期 2, 页码 143-149出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3054
关键词
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资金
- Division of AIDS of the National Institute of Allergy and Infectious Diseases of the US National Institutes of Health (NIH)
- Ragon Institute
- Center for HIV/AIDS Immunology and Immunogen Discovery
- NIH [U19AI090970, P01AI096187]
- Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]
- US Department of Defense
- [R01AI094602-01]
- [R01 AI091450-01]
CD4(+) T cells can perform a panoply of tasks to shape an effective response against a pathogen. Limited attention has been paid to the potential importance of functional CD4(+) T cell responses in the context of the development of next-generation vaccines, including HIV vaccines. Many CD4(+) T cell functions are newly appreciated and only partially understood. A workshop was held as a forum to bring together a small group of experts to exchange ideas on the role of CD4(+) T cells in developing durable functional antibody responses, via follicular helper T cells, as well as on the roles of CD4(+) T cells in other aspects of protective immunity. Here we discuss whether CD4(+) T cell responses may represent a beneficial component of an efficacious HIV vaccine.
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