期刊
NATURE MEDICINE
卷 19, 期 4, 页码 418-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3104
关键词
-
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [DK090305]
- National Cancer Institute Intramural Research Program
Co-therapy with rifampicin (RIF) and isoniazid (INH) used to treat tuberculosis in humans frequently causes liver injury. Here, using a pregnane X receptor (PXR)-humanized mouse model, we found that co-treatment with RIF and INH causes accumulation of the endogenous hepatotoxin protoporphyrin IX in the liver through PXR-mediated alteration of the heme biosynthesis pathway. These results provide insight into the mechanism of liver injury induced by co-treatment with these compounds and may lead to their safer use in the clinic.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据