期刊
NATURE MEDICINE
卷 18, 期 3, 页码 385-387出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2633
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资金
- US National Institute on Drug Abuse [R01DA15146]
- US National Institute on Alcohol Abuse and Alcoholism [R01AA16157]
For centuries, opioid drugs have been the mainstay of chronic pain treatment. However, over time analgesic tolerance develops, leaving few treatment options. Here we show that platelet-derived growth factor receptor-beta (PDGFR-beta)-mediated signaling plays a key role in morphine tolerance. PDGFR-beta inhibition selectively eliminates morphine tolerance in rats. PDGFR-beta inhibitors are widely used and well tolerated, suggesting that clinical translation of our findings could reduce the suffering endured by individuals with intractable pain.
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