期刊
NATURE MEDICINE
卷 18, 期 8, 页码 1297-+出版社
NATURE PORTFOLIO
DOI: 10.1038/nm.2823
关键词
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资金
- US National Institutes of Health [R01 CA157277, R01 EB000712, R01 EB008085, R01 CA134539, P41-EB2182, U54 CA136398]
- Korea Research Foundation
- Korean government [KRF-2007-357-C00039]
At present, clinicians routinely apply ultrasound endoscopy in a variety of interventional procedures that provide treatment solutions for diseased organs. Ultrasound endoscopy not only produces high-resolution images, but also is safe for clinical use and broadly applicable. However, for soft tissue imaging, its mechanical wave-based image contrast fundamentally limits its ability to provide physiologically specific functional information. By contrast, photoacoustic endoscopy possesses a unique combination of functional optical contrast and high spatial resolution at clinically relevant depths, ideal for imaging soft tissues. With these attributes, photoacoustic endoscopy can overcome the current limitations of ultrasound endoscopy. Moreover, the benefits of photoacoustic imaging do not come at the expense of existing ultrasound functions; photoacoustic endoscopy systems are inherently compatible with ultrasound imaging, thereby enabling multimodality imaging with complementary contrast. Here we present simultaneous photoacoustic and ultrasonic dual-mode endoscopy and show its ability to image internal organs in vivo, thus illustrating its potential clinical application.
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