4.8 Article

Taming the dragon: genomic biomarkers to individualize the treatment of cancer

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NATURE MEDICINE
卷 17, 期 3, 页码 304-312

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NATURE PORTFOLIO
DOI: 10.1038/nm.2311

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  1. Dutch Cancer Society
  2. The Netherlands Organisation for Scientific Research
  3. European Research Council
  4. National Health and Medical Research Council of Australia

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The gradual shift from cytotoxic drugs to highly selective, targeted therapeutic agents for cancer requires a parallel effort to characterize cancers at the molecular level to guide the choice of therapy for the individual patient. Here we review the genomic technologies that can be used to develop these drug response indicators, or biomarkers. We also discuss hurdles in their development and the implementation of biomarkers in clinical practice.

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