PPAR-γ action: it's all in your head

Thiazolidinediones (TZDs) target peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and are widely prescribed to treat type 2 diabetes but are associated with substantial weight gain. This side effect of TZDs is now shown to be mediated via brain PPAR-gamma. These findings suggest an important role for brain PPAR-gamma in obesity and have major implications for the clinical use of TZDs (pages 623-626 and 618-622).