期刊
NATURE MEDICINE
卷 16, 期 9, 页码 995-997出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2203
关键词
-
资金
- Center for Infectious Disease Control of The Netherlands National Institute for Public Health and the Environment
- Dutch AIDS fund [2004064]
- Netherlands Organization for Scientific research [918.66.628]
By comparing HIV-1 variants from people who became infected at the beginning of the epidemic and from people who have recently contracted the virus, we observed an enhanced resistance of the virus to antibody neutralization over time, accompanied by an increase in the length of the variable loops and in the number of potential N-linked glycosylation sites on the HIV-1 envelope gp120 subunit. The enhanced neutralization resistance of HIV-1 in contemporary seroconverters coincided with the poorer elicitation of neutralizing antibody responses, which may have implications for vaccine design.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据