期刊
NATURE MEDICINE
卷 16, 期 9, 页码 1035-U135出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2198
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资金
- US National Institutes of Health [CA140476]
- US National Science Foundation [DMR-02-13282]
- US National Cancer Institute [P30-CA14051]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [GRANTS:13714308, 0819762] Funding Source: National Science Foundation
- National Research Foundation of Korea [2010-0007782] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A major limitation of cell therapies is the rapid decline in viability and function of the transplanted cells. Here we describe a strategy to enhance cell therapy via the conjugation of adjuvant drug-loaded nanoparticles to the surfaces of therapeutic cells. With this method of providing sustained pseudoautocrine stimulation to donor cells, we elicited marked enhancements in tumor elimination in a model of adoptive T cell therapy for cancer. We also increased the in vivo repopulation rate of hematopoietic stem cell grafts with very low doses of adjuvant drugs that were ineffective when given systemically. This approach is a simple and generalizable strategy to augment cytoreagents while minimizing the systemic side effects of adjuvant drugs. In addition, these results suggest therapeutic cells are promising vectors for actively targeted drug delivery.
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