期刊
NATURE MEDICINE
卷 15, 期 3, 页码 277-284出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.1929
关键词
-
资金
- US National Institutes of Health [AI-15608, HL-33391, AI37293, AI057992]
Activated antigen-specific T cells produce a variety of effector molecules for clearing infection but also contribute to inflammation and tissue injury. Here we report an anti-inflammatory property of antiviral CD8(+) and CD4(+) effector T cells (T-eff cells) in the infected periphery during acute virus infection. We find that, during acute influenza infection, interleukin-10 (IL-10) is produced in the infected lungs in large amounts-exclusively by infiltrating virus-specific Teff cells, with CD8(+) Teff cells contributing a larger fraction of the IL-10 produced. These Teff cells in the periphery simultaneously produce IL-10 and proinflammatory cytokines and express lineage markers characteristic of conventional T helper type 1 or T cytotoxic type 1 cells. Notably, blocking the action of the T-eff cell-derived IL-10 results in enhanced pulmonary inflammation and lethal injury. Our results show that antiviral Teff cells exert regulatory functions-that is, they fine-tune the extent of lung inflammation and injury associated with influenza infection by producing an anti-inflammatory cytokine. We discuss the potential implications of these findings for infection with highly pathogenic influenza viruses.
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