期刊
NATURE MEDICINE
卷 15, 期 8, 页码 876-878出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.1989
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资金
- US National Institutes of Health Integrated Preclinical/Clinical AIDS Vaccine Development [U19AI074078]
The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5-HIV-1 vectors in the Merck STEP trial remain unclear. We find that Ad5 serostatus does not predict Ad5-specific CD4(+) T cell frequency, and we did not observe durable significant differences in Ad5-specific CD4(+) T cells between Ad5-seropositive and Ad5-seronegative subjects after vaccination. These findings indicate no causative role for Ad5-specific CD4(+) T cells in increasing HIV-1 susceptibility in the STEP trial. (C) 2009 Nature America, Inc. All rights reserved.
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