期刊
NATURE MATERIALS
卷 13, 期 11, 页码 1063-1071出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMAT4062
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资金
- Merck Fellowship of the Damon Runyon Cancer Research Foundation [DRG-2065-10]
- Howard Hughes Medical Institute
- National Institutes of Health [CA129933, EB002503, CA135601, GM092804]
During cancer progression, malignant cells in the tumour invade surrounding tissues. This transformation of adherent cells to a motile phenotype has been associated with the epithelial-mesenchymal transition (EMT). Here, we show that EMT-activated cells migrate through micropillar arrays as a collectively advancing front that scatters individual cells. Individual cells with few neighbours dispersed with fast, straight trajectories, whereas cells that encountered many neighbours migrated collectively with epithelial biomarkers. We modelled these emergent dynamics using a physical analogy to phase transitions during binary-mixture solidification, and validated it using drug perturbations, which revealed that individually migrating cells exhibit diminished chemosensitivity. Our measurements also indicate a degree of phenotypic plasticity as cells interconvert between individual and collective migration. The study of multicellular behaviours with single-cell resolution should enable further quantitative insights into heterogeneous tumour invasion.
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