期刊
NATURE MATERIALS
卷 13, 期 7, 页码 748-755出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMAT3949
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资金
- GlaxoSmithKline
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Engineering and Physical Sciences Research Council (EPSRC) [BB/H53052X/1, EP/H005625/1, EP/G042462/1]
- Engineering and Physical Sciences Research Council [EP/G042462/1, EP/H005625/1] Funding Source: researchfish
- EPSRC [EP/H005625/1, EP/G042462/1] Funding Source: UKRI
The detection and inactivation of pathogenic strains of bacteria continues to be an important therapeutic goal. Hence, there is a need for materials that can bind selectively to specific microorganisms for diagnostic or anti-infective applications, but that can be formed from simple and inexpensive building blocks. Here, we exploit bacterial redox systems to induce a copper-mediated radical polymerization of synthetic monomers at cell surfaces, generating polymers in situ that bind strongly to the microorganisms that produced them. This 'bacteria-instructed synthesis' can be carried out with a variety of microbial strains, and we show that the polymers produced are self-selective binding agents for the 'instructing' cell types. We further expand on the bacterial redox chemistries to 'click' fluorescent reporters onto polymers directly at the surfaces of a range of clinical isolate strains, allowing rapid, facile and simultaneous binding and visualization of pathogens.
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