期刊
NATURE MATERIALS
卷 12, 期 8, 页码 741-746出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMAT3647
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资金
- DoD/NSSEFF/NPS [N00244-09-1-0012, N00244-09-1-0071]
- AFOSR [FA9550-11-1-0275, FA9550-12-1-0280, FA9550-09-1-0294]
- National Science Foundation's MRSEC programme at the Materials Research Center of Northwestern University [DMR-0520513]
- Defense Advanced Research Projects Agency (DARPA)/Microsystems Technology Office (MTO) [HR0011-13-2-0002, HR0011-13-2-0018, N66001-11-1-4189]
- Non-equilibrium Energy Research Center (NERC), an Energy Frontier Research Center
- US DOE, Office of Science, Office of Basic Energy Sciences [DE-SC0000989]
- Northwestern University
- Croucher Foundation
- HHMI
- DOE [DE-AC02-06CH11357]
Nanoparticles can be combined with nucleic acids to programme the formation of three-dimensional colloidal crystals where the particles' size, shape, composition and position can be independently controlled(1-7). However, the diversity of the types of material that can be used is limited by the lack of a general method for preparing the basic DNA-functionalized building blocks needed to bond nanoparticles of different chemical compositions into lattices in a controllable manner. Here we show that by coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide-alkyne cycloaddition(8) (also known as copper-free azide-alkyne click chemistry), nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition. This method provides a route to a virtually endless class of programmable atom equivalents for DNA-based colloidal crystallization.
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