期刊
NATURE MATERIALS
卷 11, 期 12, 页码 1065-1073出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMAT3468
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资金
- National Institutes of Health Challenge Grant in Health and Science Research from the National Institute of Neurological Disorders and Stroke [1RC1NS068396-0110]
- Center for Neural Communication Technology, a P41 Resource Center
- National Institute of Biomedical Imaging and Bioengineering [P41 EB002030]
- DARPA STTR grant [W31P4Q-08-C-0426]
- NeuroNexus Technologies
Implantable neural microelectrodes that can record extracellular biopotentials from small, targeted groups of neurons are critical for neuroscience research and emerging clinical applications including brain-controlled prosthetic devices. The crucial material-dependent problem is developing microelectrodes that record neural activity from the same neurons for years with high fidelity and reliability. Here, we report the development of an integrated composite electrode consisting of a carbon-fibre core, a poly(p-xylylene)-based thin-film coating that acts as a dielectric barrier and that is functionalized to control intrinsic biological processes, and a poly(thiophene)-based recording pad. The resulting implants are an order of magnitude smaller than traditional recording electrodes, and more mechanically compliant with brain tissue. They were found to elicit much reduced chronic reactive tissue responses and enabled single-neuron recording in acute and early chronic experiments in rats. This technology, taking advantage of new composites, makes possible highly selective and stealthy neural interface devices towards realizing long-lasting implants.
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