期刊
NATURE MATERIALS
卷 9, 期 6, 页码 485-490出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMAT2766
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资金
- FP7 Anticarb [HEALTH-2007-201587]
- EPSRC LSI
- Samsung Scholarship Foundation
- European Community
- Ramon y Cajal Programmes
- MICINN Spain
- INSS Japan
- Thomas Swan Co. Ltd.
- Ministere de l'Enseignement Superieur et de la Recherche Scientifique (Algeria)
- Royal Society-Wolfson Research
- Biotechnology and Biological Sciences Research Council [BB/C510824/1, BB/E004350/1, EGA17763] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/E000614/1, EP/D023335/1, GR/T26542/01, EP/G026688/1, EP/F048009/1, EP/D023343/1] Funding Source: researchfish
- BBSRC [BB/E004350/1] Funding Source: UKRI
- EPSRC [EP/E000614/1, EP/F048009/1, EP/G026688/1] Funding Source: UKRI
Functionalization of nanomaterials for precise biomedical function is an emerging trend in nanotechnology(1.) Carbon because payload can be encapsulated in internal space whilst outer surfaces can be chemically modified(2). Yet, despite potential as drug delivery systems(3,4) and radiotracers(5-8), such filled-and- functionalized carbon nanotubes have not been previously investigated in vivo. Here we report covalent functionalization of radionuclide-filled single-walled carbon nanotubes and their use as radioprobes. Metal halides, including (NaI)-I-125, were sealed inside single-walled carbon nanotubes to create high-density radioemitting crystals(9) and then surfaces of these filled-sealed nanotubes were covalently modified with biantennary carbohydrates, improving dispersibility and biocompatibility(10). Intravenous administration of (NaI)-I-125-filled glyco-single-walled carbon nanotubes in mice was tracked in vivo using single-photon emission computed tomography. Specific tissue accumulation (here lung) coupled with high in vivo stability prevented leakage of radionuclide to high-affinity organs (thyroid/stomach) or excretion, and resulted in ultrasensitive imaging and delivery of unprecedented radiodose density. Nanoencapsulation of iodide within single-walled carbon nanotubes enabled its biodistribution to be completely redirected from tissue with innate affinity (thyroid) to lung. Surface functionalization of I-125-filled single-walled carbon nanotubes offers versatility towards modulation of biodistribution of these radioemitting crystals in a manner determined by the capsule that delivers them. We envisage that organ- specific therapeutics and diagnostics can be developed on the basis of the nanocapsule model described here.
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