期刊
NATURE IMMUNOLOGY
卷 19, 期 10, 页码 1093-+出版社
NATURE RESEARCH
DOI: 10.1038/s41590-018-0201-4
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资金
- National Institutes of Health [AI030663, HL128903, AI122702, DK101604, AI113143]
- Dermatology Foundation
- A.P. Giannini Foundation
- Robert Wood Johnson Foundation
- Swiss National Science Foundation [P2EZP3_162266, P300PA_171591]
- Howard Hughes Medical Institute
- Sandler Asthma Basic Research Center at the University of California San Francisco
- Swiss National Science Foundation (SNF) [P300PA_171591, P2EZP3_162266] Funding Source: Swiss National Science Foundation (SNF)
Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP). Transcriptional profiling of ILC2s from different tissues, however, grouped ILC2s according to their tissue of origin, even in the setting of combined IL-25-, IL-33-receptor-, and TSLP-receptor-deficiency. Single-cell profiling confirmed a tissue-organizing transcriptome and identified ILC2 subsets expressing distinct activating receptors, including the major subset of skin ILC2s, which were activated preferentially by IL-18. Tissue ILC2 subsets were unaltered in number and expression in germ-free mice, suggesting that endogenous, tissue-derived signals drive the maturation of ILC2 subsets by controlling expression of distinct patterns of activating receptors, thus anticipating tissue-specific perturbations occurring later in life.
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