期刊
NATURE IMMUNOLOGY
卷 15, 期 4, 页码 323-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2833
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资金
- US National Institutes of Health [AI53825, CA164062, AI091965, CA158823, AI049823]
- Netherlands Organisation for Scientific Research
- Arthritis Society of Canada
The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs). However, the metabolic requirements that support this process remain poorly defined. We found that DC glycolytic flux increased within minutes of exposure to TLR agonists and that this served an essential role in supporting the de novo synthesis of fatty acids for the expansion of the endoplasmic reticulum and Golgi required for the production and secretion of proteins that are integral to DC activation. Signaling via the kinases TBK1, IKK. and Akt was essential for the TLR-induced increase in glycolysis by promoting the association of the glycolytic enzyme HK-II with mitochondria. In summary, we identified the rapid induction of glycolysis as an integral component of TLR signaling that is essential for the anabolic demands of the activation and function of DCs.
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