期刊
NATURE IMMUNOLOGY
卷 15, 期 9, 页码 798-807出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2940
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资金
- US National Institutes of Health [PO1 AI091580]
The initiation of T cell antigen receptor signaling is a key step that can result in T cell activation and the orchestration of an adaptive immune response. Early events in T cell receptor signaling can distinguish between agonist and endogenous ligands with exquisite selectivity, and show extraordinary sensitivity to minute numbers of agonists in a sea of endogenous ligands. We review our current knowledge of models and crucial molecules that aim to provide a mechanistic explanation for these observations. Building on current understanding and a discussion of unresolved issues, we propose a molecular model for initiation of T cell receptor signaling that may serve as a useful guide for future studies.
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