期刊
NATURE IMMUNOLOGY
卷 14, 期 7, 页码 654-659出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2614
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资金
- Ruth L. Kirschstein National Research Service Award [F32 DK089718]
- Howard Hughes Medical Institute
- US National Institutes of Health [R01 DK070855]
- Burroughs Wellcome Foundation Investigators in the Pathogenesis of Infectious Diseases award
The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota-immune system interactions for human health.
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