期刊
NATURE IMMUNOLOGY
卷 14, 期 11, 页码 1190-U118出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2712
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- Division of Intramural Research of the NHLBI and NIAID (US National Institutes of Health)
Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identified 1,524 lincRNA clusters in 42 T cell samples, from early T cell progenitors to terminally differentiated helper T cell subsets. Our analysis revealed highly dynamic and cell-specific expression patterns for lincRNAs during T cell differentiation. These lincRNAs were located in genomic regions enriched for genes that encode proteins with immunoregulatory functions. Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6. We found that the lincRNA LincR-Ccr2-5'AS, together with GATA-3, was an essential component of a regulatory circuit in gene expression specific to the T(H)2 subset of helper T cells and was important for the migration of T(H)2 cells.
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