期刊
NATURE IMMUNOLOGY
卷 14, 期 8, 页码 793-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2647
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资金
- National Key Basic Research Program of China [2012CB519000]
- National Megaprojects of China for Infectious Diseases [2012ZX10002007-001]
- German Research Foundation [SFB/Transregio TRR60]
- National Natural Science Foundation of China [31200129]
- China Postdoctoral Science Foundation [201104232]
The cell-to-cell transmission of viral resistance is a potential mechanism for amplifying the interferon-induced antiviral response. In this study, we report that interferon-alpha (IFN-alpha) induced the transfer of resistance to hepatitis B virus (HBV) from nonpermissive liver nonparenchymal cells (LNPCs) to permissive hepatocytes via exosomes. Exosomes from IFN-alpha-treated LNPCs were rich in molecules with antiviral activity. Moreover, exosomes from LNPCs were internalized by hepatocytes, which mediated the intercellular transfer of antiviral molecules. Finally, we found that exosomes also contributed to the antiviral response of IFN-alpha to mouse hepatitis virus A59 and adenovirus in mice. Thus, we propose an antiviral mechanism of IFN-alpha activity that involves the induction and intercellular transfer of antiviral molecules via exosomes.
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