期刊
NATURE IMMUNOLOGY
卷 15, 期 1, 页码 27-35出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2782
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资金
- Pasteur Institute
- INSERM
- Agence Nationale de Recherche (grant 'Lymphopoiesis')
- REVIVE Future Investment Program
- La Ligue contre le Cancer
The generation of T cells depends on the migration of hematopoietic progenitor cells to the thymus throughout life. The identity of the thymus-settling progenitor cells has been a matter of considerable debate. Here we found that thymopoiesis was initiated by a first wave of T cell lineage-restricted progenitor cells with limited capacity for population expansion but accelerated differentiation into mature T cells. They gave rise to alpha beta and gamma delta T cells that constituted V(gamma)3(+) dendritic epithelial T cells. Thymopoiesis was subsequently maintained by less-differentiated progenitor cells that retained the potential to develop into B cells and myeloid cells. In that second wave, which started before birth, progenitor cells had high proliferative capacity but delayed differentiation capacity and no longer gave rise to embryonic gamma delta T cells. Our work reconciles conflicting hypotheses on the nature of thymus-settling progenitor cells.
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