期刊
NATURE IMMUNOLOGY
卷 15, 期 1, 页码 80-87出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2773
关键词
-
类别
资金
- Cancer Research UK
- Marie Curie Actions
- University College London MBPhD programme
- Wellcome Trust
- Cancer Research UK [19309] Funding Source: researchfish
- Medical Research Council [1415536] Funding Source: researchfish
The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity. In studies that explain how such cells can straddle innate and adaptive immunity, we found that signaling via antigen receptors, whose conventional role is to facilitate clonal T cell activation, was critical for the development of innate-like T cells but then was rapidly attenuated, which accommodated the cells' innate responsiveness. These findings permitted the identification of a previously unknown innate-like T cell subset and indicate that T cell hyporesponsiveness, a state traditionally linked to tolerance, may be fundamental to T cells entering the innate compartment and thereby providing lymphoid stress surveillance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据