期刊
NATURE IMMUNOLOGY
卷 14, 期 8, 页码 777-784出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2636
关键词
-
类别
资金
- Swiss National Science Foundation [31003A_138343]
- Novartis Stiftung fur Medizinisch Biologische Forschung
- European Research Council
- Swiss National Science Foundation (SNF) [31003A_138343] Funding Source: Swiss National Science Foundation (SNF)
Standard definitions of immunological memory are all built on the idea that once infected, animals are protected more efficiently against a second infection. This common view overlooks an unavoidable consequence of the exposure of cells to pathogens, danger signals and environmental agents in general: stimuli change cell properties and activity in a transient yet sustained manner that extends beyond the exposure time and modulates the response of cells of both the innate and adaptive immune systems to secondary stimulation. We suggest that this transient phenomenon represents 'short-term memory' of environmental exposure and discuss the evidence that this is mediated by the persistence of long-lived regulatory molecules, notably a subset of newly deposited chromatin modifications and inducible noncoding RNAs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据